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up to 25 mg daily oral) Ozempic provides moderate doses (up to 2 mg weekly) Rybelsus has the lowest maximum dose (14 mg daily) due to poor oral absorption Effectiveness for Weight Loss Wegovy (injectable) : Most effective (12-15% body weight loss) Wegovy (oral pill) : Nearly as effective (~13.7% body weight loss) Ozempic : Moderately effective (10-12% body weight loss) Rybelsus : Least effective for weight loss (~4-6% body weight loss) Insurance Coverage and Cost Without Insurance: Ozempic: ~$900-1,000/month Wegovy (injectable): ~$1,300-1,400/month Wegovy (oral pill): $149/month (starting dose) Rybelsus: ~$975-1,200/month With Insurance: Patients with commercial insurance and manufacturer savings cards may pay as little as $25/month for Ozempic or Wegovy Medicare Part D plans will cover these medications starting in 2027 at reduced costs of approximately $274/month Many insurance plans cover Ozempic and Rybelsus for diabetes but may not cover Wegovy for weight loss alone Can You Switch Between These Medications